PubMed
Postdoctoral:
35. Norambuena J, Al-Tameemi H, Boverman H, Kim J, Beavers WN, Skaar EP, Parker D, Boyd JM. Copper ions inhibit pentose phosphate pathway function in Staphylococcus aureus. PLoS Path. (2023) doi: 10.1371/journal.ppat.1011393. PMCID: PMC10249872.
34. Voss K, Sewell AE, Krystofiak ES, Gibson-Corley KN, Young AC, Basham JH, Sugiura A, Arner EN, Beavers WN, Kunkle DE, Dickson ME, Needle GA, Skaar EP, Rathmell WK, Ormseth MJ, Major AS, Rathmell JC. Elevated transferrin receptor impairs T cell metabolism and function in systemic lupus erythematosus. Sci. Immunol. (2023) doi: 10.1126/sciimmunol.abq0178. PMCID: PMC9936798.
33. Afzal A, Beavers WN, Skaar EP, Calhoun MC, Richardson KA, Landstreet SR, Cliffel DE, Wright D, Bastarache JA, Ware LB. Ultraviolet light oxidation of fresh hemoglobin eliminates aggregate formation seen in commercially sourced hemoglobin. Blood Cells, Mol. and Dis. (2023) PMCID: PMC10024311.
32. Ameka MK, Beavers WN, Shaver CM, Ware LB, Kerchberger VE, Schoenfelt KQ, Sun L, Koyama T, Skaar EP, Becker L, Hasty AH. An iron refractory phenotype in obese adipose tissue macrophages leads to adipocyte iron overload. Int. J. Mol. Sci. (2022) doi: 10.3390/ijms23137417. PMCID: PMC9267114..
31. Weiss A, Murdoch CC, Edmonds KA, Jordan MR, Monteith AJ, Perera YR, Rodríguez Nassif AM, Petoletti AM, Beavers WN, Munneke MJ, Drury SL, Krystofiak ES, Thalluri K, Wu H, Kruse ARS, DiMarchi RD, Caprioli RM, Spraggins JM, Chazin WJ, Giedroc DP, Skaar EP. Zn regulated GTPase metalloprotein activator 1 (ZNG1) regulates zinc homeostasis in vertebrates. Cell. (2022) doi: 10.1016/j.cell.2022.04.011. PMCID: PMC9189065.
30. Beavers WN, Munneke MJ, Stackhouse AR, Freiberg JA, Skaar EP. Host polyunsaturated fatty acids potentiate aminoglycoside killing of Staphylococcus aureus. Microbiol. Spectr. (2022) doi:10.1128/spectrum.02767-21. PMCID: PMC9045252.
29. Monteith AJ, Miller JM, Beavers WN, Juttukonda LJ, Skaar EP. Increased dietary manganese impairs NET formation rendering neutrophils ineffective at combatting Staphylococcus aureus. Infect. Immun. (2022) doi:10.1128/iai.00685-21. PMCID: PMC8929375.
28. Monteith AJ, Miller JM, Beavers WN, Maloney KN, Seifert E, Hajnoczky G, Skaar EP. Mitochondrial calcium uniporter affects neutrophil bactericidal activity during Staphylococcus aureus infection. Infect. Immun. (2022) doi: 10.1128/IAI.00551-21. PMCID: PMC8853686.
27. Weiss A, Lopez CA, Beavers WN, Rodriguez J, Skaar EP. Clostridioides difficile strain dependent and independent adaptations to a microaerobic environment. Microb. Genom. (2021) doi: 10.1099/mgen.0.000738. PMCID: 8767335.
26. Wexler AG, Guiberson ER, Beavers WN, Washington MK, Caprioli RM, Spraggins JM, Skaar EP. Clostridioides difficile infection induces a rapid influx of bile acids into the gut to facilitate colonization of the host. Cell Rep. (2021) doi: 10.1016/j.celrep.2021.109683. PMCID: PMC8445666.
25. Beavers WN, DuMont AL, Monteith AJ, Maloney KN, Tallman KA, Weiss A, Christian AH, Toste FD, Chang CJ, Porter NA, Torres VJ, Skaar EP. Staphylococcus aureus peptide methionine sulfoxide reductases protect from human whole blood killing. Infect. Immun. (2021) doi: 10.1128/IAI.00146-21. PMCID: PMC8281210.
24. Juttukonda LJ*, Beavers WN*, Unsihuay D, Kim K, Pishchany G, Horning KJ, Weiss A, Al-Tameemi H, Boyd JM, Sulikowski GA, Bowman AB, Skaar EP. A small-molecule modulator of metal homeostasis in Gram-positive pathogens. MBio. (2020) doi: 10.1128/mBio.02555-20. PMCID: PMC7593973. (*equal authorship)
23. Bozhanova NG, Calcutt MW, Beavers WN, Brown BP, Skaar EP, Meiler J. Lipocalin Blc is a heme binding protein. FEBS Lett. (2020) doi: 10.1002/1873-3468.14001. PMCID: PMC8177097.
22. Al-Tameemi H, Beavers WN, Norambuena J, Skaar EP, Boyd JM. Staphylococcus aureus lacking a functional MntABC manganese import system have increased resistance to copper. Mol. Microbiol. (2020) doi: 10.1111/mmi.14623. PMCID: PMC8121185.
21. Becker SH, Ulrich K, Dhabaria A, Ueberheide B, Beavers WN, Skaar EP, Iyer LM, Aravind L, Jakob U, Darwin KH. Mycobacterium tuberculosis Rv0991c is a novel redox-regulated molecular chaperone. MBio. (2020) doi: 10.1128/mBio.01545-20. PMCID: PMC7448276.
20. Knippel RJ, Wexler AG, Miller JM, Beavers WN, Weiss A, de Crécy-Lagard V, Edmonds KA, Giedroc DP, Skaar EP. Clostridioides difficile senses and hijacks host heme for incorporation into an oxidative stress defense system. Cell Host Microbe. (2020) doi: 10.1016/j.chom.2020.05.015. PMCID: PMC7486240.
19. Lopez CA, McNeely T, Nurmakova K, Beavers WN, Skaar EP. Clostridioides difficile proline fermentation in response to commensal Clostridia. Anaerobe. (2020) doi: 10.1016/j.anaerobe.2020.102210. PMCID: PMC8025294.
18. Zackular JP, Knippel RJ, Lopez CA, Beavers WN, Maxwell CN, Chazin WJ, Skaar EP. ZupT facilitates Clostridioides difficile resistance to host-mediated nutritional immunity. mSphere. (2020) doi: 10.1128/mSphere.00061-20. PMCID: PMC7067591.
17. Lopez CA, Beavers WN, Weiss A, Knippel RJ, Zackular JP, Chazin WJ, Skaar EP. The immune protein calprotectin impacts Clostridioides difficile metabolism through zinc limitation. MBio. (2019) doi: 10.1128/mBio.02289-19. PMCID: PMC6867894.
16. Hesse LE, Lonergan ZR, Beavers WN, Skaar EP. The Acinetobacter baumannii Znu system overcomes host-imposed nutrient zinc limitation. Infect. Immun. (2019) doi:10.1128/IAI.00746-19. PMCID: PMC6867866.
15. Beavers WN, Monteith AJ, Amarnath V, Mernaugh RL, Roberts II LJ, Chazin WJ, Davies SS, Skaar EP. Arachidonic acid kills Staphylococcus aureus through a lipid peroxidation mechanism. MBio. (2019) doi: 10.1128/mBio.01333-19. PMCID: PMC6775451.
14. Palmer LD, Jordan AT, Maloney KN, Farrow MA, Gutierrez DB, Grant-Branum R, Burns WJ, Romer CE, Tsui T, Allen JL, Beavers WN, Nei YW, Sherrod SD, Lacy DB, Norris JL, McLean JA, Caprioli RM, Skaar EP. Zinc intoxication induces ferroptosis in A549 human lung cells. Metallomics. (2019) doi: 10.1039/c8mt00360b. PMCID: PMC6531343.
13. Grunenwald CM, Choby JE, Beavers WN, Weiss A, Juttukonda LJ, Skaar EP. Manganese detoxification by MntE is critical for resistance to oxidative stress and virulence of Staphylococcus aureus. MBio. (2019) doi: 10.1128/mBio.02915-18. PMCID: PMC6391924.
12. Lonergan ZR, Nairn BL, Hsu YP, Wang J, Hesse LE, Beavers WN, Chazin WJ, VanNieuwehhze MS, Giedroc DP, Skaar EP. An Acinetobacter baumannii, zinc-regulated peptidase maintains cell wall integrity during immune-mediated nutrient sequestration. Cell Rep. (2019) doi: 10.1016/j.clrep.2019.01.089. PMCID: PMC6441547.
11. Juttukonda LJ, Zackular JP, Moore JL, Berends ETM, Zhang Y, Schmitz JE, Beavers WN, Wijers CD, Gilston BA, Kehl-Fie T, Atkinson J, Washington MK, Torres VJ, Chazin WJ, Caprioli RM, Skaar EP. Dietary manganese promotes staphylococcal infection in the heart. Cell Host Microbe. (2017) doi: 10.1016/j.chom.2017.08.009. PMCID: PMC5638708.
10. Noto MJ, Burns WJ, Beavers WN, Skaar EP. Mechanisms of pyocyanin toxicity and genetic determinants of resistance in Staphylococcus aureus. J Bacteriol. (2017) doi: 10.1128/JB.00221-17. PMCID: PMC5553028.
9. Beavers WN, Skaar EP. Neutrophil generated oxidative stress and protein damage in Staphylococcus aureus. Pathog. Dis. (2016) doi: 10.1093/femspd/ftw060. PMCID: PMC5975594.
Graduate:
8. Galligan JJ, Wepy JA, Streeter MD, Kingsley PJ, Mitchener MM, Wauchope OR, Beavers WN, Rose KL, Wang T, Spiegel DA, Marnett LJ. Methylglyoxal-derived post-translational arginine modifications are abundant histone marks. Proc. Natl. Acad. Sci. U.S.A. (2018) doi: 10.1073/pnas.1802901115. PMCID: PMC6140490.
7. Wauchope OR, Mitchener MM, Beavers WN, Galligan JJ, Camarillo JM, Sanders WD, Kingsley PJ, Shim HN, Blackwell T, Luong T, deCaestecker M, Fessel JP, Marnett LJ. Oxidative stress increases M1dG, a major peroxidation-derived DNA adduct, in mitochondrial DNA. Nucleic Acids Res. (2018) doi: 10.1093/nar/gky089. PMCID: PMC5909422.
6. Beavers WN, Rose KL, Galligan JJ, Mitchener MM, Tallman KA, Lamberson CR, Wang X, Hill SS, Ivanova P, Brown HA, Zhang B, Porter NA, Marnett LJ. Protein modification by endogenously generated lipid electrophiles: mitochondria as the source and target. ACS Chem. Biol. (2017) doi: 10.1021/acschembio.7b00480. PMCID: PMC6174696.
5. Wauchope OR, Beavers WN, Galligan JJ, Mitchener MM, Kingsley PJ, Marnett LJ. Nuclear oxidation of a major peroxidation DNA adduct, M1dG, in the genome. Chem. Res. Toxicol. (2015) doi: 10.1021/acs.chemrestox.5b00340. PMCID: PMC4993022.
4. Beavers WN*, Serwa R*, Shimozu Y, Tallman KA, Vaught M, Dalvie ED, Marnett LJ, Porter NA. ω-Alkynyl lipid surrogates for polyunsaturated fatty acids: free radical and enzymatic oxidations. J. Am. Chem. Soc. (2014) doi: 10.1021/ja506038v. PMCID: PMC4140476. (*equal authorship)
3. Codreanu SG, Ullery JC, Zhu J, Tallman KA, Beavers WN, Porter NA, Marnett LJ, Zhang B, Liebler DC. Alkylation damage by lipid electrophiles targets functional protein systems. Mol. Cell. Proteom. (2014) doi: 10.1074/mcp.M113.032953. PMCID: PMC3945913.
2. Galligan JJ, Rose KL, Beavers WN, Hill SS, Tallman KA, Tansey W, Marnett LJ. Stable histone adduction by 4-oxo-2-nonenal: a potential link between oxidative stress and altered gene expression. J. Am. Chem. Soc. (2014) doi: 10.1021/ja503604t. PMCID: PMC4151707.
1. Shuck SC, Wauchope OR, Rose KL, Kingsley PK, Rouzer CA, Shell SM, Sugitani N, Chazin WJ, Zagol-Ikapitte I, Boutaud O, Oates JA, Galligan JJ, Beavers WN, Marnett LJ. Protein modification by adenine propenal. Chem. Res. Toxicol. (2014) doi: 10.1021/tx500218g. PMCID: PMC4203390.